polyomavirus small t antigens การใช้

• Merkel cell polyomavirus small T antigen encodes a unique domain, called the LT-stabilization domain ( LSD ), that binds to and inhibits the FBXW7 E3 ligase regulating both cellular and viral oncoproteins.
• Polyomavirus small T antigens commonly target protein phosphatase 2A ( PP2A ), a key multisubunit regulator of multiple pathways including Akt, the mitogen-activated protein kinase ( MAPK ) pathway, and the stress-activated protein kinase ( SAPK ) pathway.